For over 30 years, Guthrie has been conducting clinical trials in the gastroenterology (GI) department.   

Local access to leading-edge research 

As a Guthrie patient you may have an opportunity to take part in clinical research trials for celiac disease, Crohn’s disease, ulcerative colitis, reflux disease, hepatitis and many more gastroenterology disease states.

Clinical trials

Clinical trials study new ways to prevent, detect and treat GI disease. If you take part in research, you help advance new investigational medical therapies. Research subjects receive excellent care locally from the Guthrie GI team, while still being able to access cutting-edge therapies offered in large university settings and metropolitan areas. 

GI trials involve preventive measures and investigational treatments and medicines. Your physician can present you with options and help you decide if a clinical trial is right for you.
Most clinical trials offered at Guthrie are phase 2 or phase 3 studies which measure safety and efficacy (whether the investigational treatment benefits a specific group of patients). 

We work with multiple labs, pharmaceutical groups, and biotech companies to offer you the chance to get innovative treatments and novel therapies, and to assist with the future of gastroenterology care. 

Title: S1802, Phase III Randomized Trial of Standard Systemic Therapy (SST) Versus Standard Systemic Therapy Plus Definitive Treatment (Surgery or Radiation) of the Primary Tumor in Metastatic Prostate Cancer).
Department: Oncology
Diagnosis: Genito-urinary - Prostate
Principal Investigator:

Poulose MD, Joyson

Sponsors: National Cancer Institute
Details (Identifier #): 03678025
Title: S1827: MRI Brain Surveillance Alone Versus MRI Surveillance and Prophylactic Cranial Irradiation (PCI): A Randomized Phase III Trial in Small-Cell Lung Cancer (MAVERICK)
Department: Oncology
Diagnosis: Lung- Small Cell
Principal Investigator:

Gergel MD, Thomas

Sponsors: SWOG Cancer Research Network
Details (Identifier #): NCT04155034
Title: S2015: Melanoma Margins Trial (MelMarT): A Phase III, Multi-Centre, Multi-National Randomised Control Trial Investigating 1cm v 2cm Wide Excision Margins for Primary Cutaneous Melanoma
Department: Oncology
Diagnosis: Melanoma
Principal Investigator:

Bertsch MD, David

Sponsors: SWOG Cancer Research Network
Details (Identifier #): NCT03860883
Title: S2302, PRAGMATICA - LUNG: A PROSPECTIVE RANDOMIZED STUDY OF RAMUCIRUMAB (LY3009806; NSC 749128) PLUS PEMBROLIZUMAB (MK-3475; NSC 776864) VERSUS STANDARD OF CARE FOR PARTICIPANTS PREVIOUSLY TREATED WITH IMMUNOTHERAPY FOR STAGE IV OR RECURRENT NON-SMALL CELL LUNG CANCER
Department: Oncology
Diagnosis: Lung- Non-Small Cell
Principal Investigator:

Poulose MD, Joyson

Sponsors: Cancer Trials Support Unit-
Details (Identifier #): NCT05633602
Title: Shorter Anthracycline-Free Chemo Immunotherapy Adapted to Pathological Response in Early Triple Negative Breast Cancer (SCARLET), A Randomized Phase III
Study
Department: Oncology
Diagnosis: Breast
Principal Investigator:

Poulose MD, Joyson

Sponsors: SWOG Cancer Research Network
Details (Identifier #): NCT05929768
Title: Tethered Enzyme Technology (TET) Assay for
Detection of COVID-19
Department: Internal Studies
Diagnosis: Infectious Disease
Principal Investigator:

Prabhu MD, Sheela

Sponsors: Internal Foundation
Details (Identifier #): None
Title: Tethered Enzyme Technology (TET) Assay for Quantitative Diagnosis of Blunt Head Trauma (BHT) and Stroke through Detection of Blood and Saliva Biomarkers
Department: Trauma
Diagnosis: Neurology
Principal Investigator:

Behm MD, Robert

Sponsors: Internal
Details (Identifier #): None
Title: The Efficacy of Steroid-Sparing Anti-Emetic Therapy in Patients Treated with High Emetogenic Chemotherapy; Single Center Non-Inferiority Open Label Randomized Controlled Trial
Department: Oncology
Diagnosis: Miscellaneous
Principal Investigator:

Ink PharmD, Nicole

Sponsors: Internal Foundation
Details (Identifier #): NCT05590923
Title: The PROACT LUNG Study: A Prospective Observational Clinical Validation Study of the Freenome Multiomics Blood Test for Lung Cancer Screening
Department: Oncology
Diagnosis: Lung- Miscellaneous
Principal Investigator:

McGinley DO, Kathleen

Sponsors: Freenome, Inc
Details (Identifier #): NCT06122077
Title: The PROACT LUNG Study: A Prospective Observational Clinical Validation Study of the Freenome Multiomics Blood Test for Lung Cancer Screening
Department: Oncology
Diagnosis: Lung- Miscellaneous
Principal Investigator:

Bertsch MD, David

Sponsors: Freenome, Inc
Details (Identifier #): NCT06122077