For over 30 years, Guthrie has been conducting clinical trials in the gastroenterology (GI) department.   

Local access to leading-edge research 

As a Guthrie patient you may have an opportunity to take part in clinical research trials for celiac disease, Crohn’s disease, ulcerative colitis, reflux disease, hepatitis and many more gastroenterology disease states.

Clinical trials

Clinical trials study new ways to prevent, detect and treat GI disease. If you take part in research, you help advance new investigational medical therapies. Research subjects receive excellent care locally from the Guthrie GI team, while still being able to access cutting-edge therapies offered in large university settings and metropolitan areas. 

GI trials involve preventive measures and investigational treatments and medicines. Your physician can present you with options and help you decide if a clinical trial is right for you.
Most clinical trials offered at Guthrie are phase 2 or phase 3 studies which measure safety and efficacy (whether the investigational treatment benefits a specific group of patients). 

We work with multiple labs, pharmaceutical groups, and biotech companies to offer you the chance to get innovative treatments and novel therapies, and to assist with the future of gastroenterology care. 

Title: LungMap (Screening Protocol for Lung-Map):
Department: Oncology
Diagnosis: Lung- Non-Small Cell
Principal Investigator:

Lowry MD, Philip

Sponsors: SWOG Cancer Research Network
Details (Identifier #): NCT03851445
Title: M21-341 Avanti, A Phase 2/3 multicenter, double blinded, randomized, dose-conversion, active control study examining the efficacy and safety of Armour Thyroid compared to synthetic T4 for the treatment of adults with primary hypothyroidism
Department: Endocrinology
Diagnosis: Endocrine - Growth Hormone
Principal Investigator:

Yavuz MD, Sahzene

Sponsors: AbbVie
Details (Identifier #): NCT06345339
Title: Molecular Analysis for Combination Therapy Choice
(ComboMATCH)
Department: Oncology
Diagnosis: Gastrointestinal - Colon-Rectal
Principal Investigator:

Poulose MD, Joyson

Sponsors: National Cancer Institute
Title: NRG-BR007: A Phase III Clinical Trial Evaluating De-Escalation of Breast Radiation for Conservative Treatment of Stage I, Hormone Sensitive, HER-2 Negative, Oncotype Recurrence Score Less Than or Equal to 18 Breast Cancer
Department: Oncology
Diagnosis: Breast- Adjuvant
Principal Investigator:

Poulose MD, Joyson

Sponsors: NRG Oncology
Details (Identifier #): NCT04852887
Title: NRG-BR009: A Phase III Adjuvant Trial Evaluating the Addition of Adjuvant
Chemotherapy to Ovarian Function Suppression plus Endocrine Therapy
in Premenopausal Patients with pN0-1, ER-Positive/HER2-Negative Breast Cancer and an Oncotype Recurrence Score ? 25 (OFSET)
Department: Oncology
Diagnosis: Breast
Principal Investigator:

Wang, Le

Sponsors: National Cancer Institute
Details (Identifier #): NCT05879926
Title: NRG-LU007: Randomized Phase II/III Trial of Consolidation Radiation + Immunotherapy for ES-SCLC: RAPTOR Trial
Department: Oncology
Diagnosis: Lung- Small Cell
Principal Investigator:

Poulose MD, Joyson

Sponsors: NRG Oncology
Details (Identifier #): NCT04402788
Title: OptimICE-PCR: De-Escalation of Therapy in Early-Stage TNBC Patients Who Achieve pCR After Neoadjuvant Chemotherapy With Checkpoint Inhibitor Therapy
Department: Oncology
Diagnosis: Breast
Principal Investigator:

Poulose MD, Joyson

Sponsors: ALLIANCE
Details (Identifier #): NCT05812807
Title: Protocol A081801 Integration of immunotherapy into adjuvant therapy for resected NSCLC: ALCHEMIST chemo-IO (ACCIO) (NCT 04267848)
Department: Oncology
Diagnosis: Lung- Non-Small Cell
Principal Investigator:

Poulose MD, Joyson

Sponsors: National Cancer Institute
Details (Identifier #): NCT04267848
Title: S-11: A multicentre, prospective clinical study analysing outcomes of shoulder arthroplasty with SMR TT Hybrid Glenoid with or without SMR Cementless Finned Short Stem
Department: Orthopedic Surgery
Diagnosis: Orthopedics
Principal Investigator:

Choi M.D., Joseph

Sponsors: LimaCorporate
Details (Identifier #): NCT05314387
Title: S1501, Carvedilol in Preventing Cardiac Toxicity in Patients With Metastatic HER-2-Positive Breast Cancer
Department: Oncology
Diagnosis: Breast- Metastatic
Principal Investigator:

Lowry MD, Philip

Sponsors: SWOG Cancer Research Network
Details (Identifier #): NCT03418961
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